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Key Takeaways Monobenzone cream is primarily prescribed to treat extensive vitiligo by permanently depigmenting Approved Medical Uses of Monobenzone Cream The primary approved indication for monobenzone is extensive vitiligo Treating Extensive Vitiligo Vitiligo is an autoimmune condition that causes loss of skin pigment in patches A dermatologist usually evaluates: Extent of vitiligo Previous treatments Medical history Skin sensitivity prescription medication designed for a very specific medical purpose: helping patients with extensive vitiligo