Tadapox Side Effects: Dizziness, Nausea, and More
Written by Elizabeth Chernoby in TheSkyMeds Editorial Standards
Medically reviewed by Jonathan Reed, Medical Content Reviewer Oct 29 2026
Tadapox side effects are important to understand because this combination tablet contains two medicines that affect the body differently. Tadapox is marketed for erectile dysfunction and premature ejaculation, commonly combining tadalafil 20 mg with dapoxetine 60 mg. While tadalafil helps improve erections, dapoxetine is intended to delay ejaculation. Both ingredients can cause unwanted effects, including dizziness, nausea, headache, and changes in blood pressure. More serious problems, such as fainting or a prolonged erection, also require attention. This guide explains common Tadapox side effects, why they happen, which combinations are risky, and when medical care is necessary.
What Is Tadapox and How Does It Work?
Tadapox is marketed as a combination medicine for men experiencing erectile dysfunction (ED) and premature ejaculation (PE).
The RSM Multilink Tadapox product information lists:
Tadalafil 20 mg: A medicine that improves blood flow to the penis during sexual stimulation.
Dapoxetine 60 mg: A short-acting selective serotonin reuptake inhibitor (SSRI) used for premature ejaculation in certain countries.
These strengths describe the marketed formulation, not a recommended starting dose.
Why Does Combining the Ingredients Matter?
Tadalafil relaxes blood vessels and can reduce blood pressure.
Dapoxetine changes serotonin activity in the nervous system and may cause dizziness or fainting.
Combining them can create additional safety concerns.
Tadapox itself is not FDA-approved in the United States, although tadalafil is approved separately for certain conditions. Dapoxetine is not FDA-approved.
Product quality and regulatory status should be checked in the country where the medicine is obtained.
What Are the Most Common Tadapox Side Effects?
The main reported effects associated with Tadapox's ingredients include nausea, dizziness, headache, flushing, indigestion, and nasal congestion.
Not everyone experiences these symptoms.
However, their likelihood may increase with higher doses or interacting medicines.
Dizziness and Light-Headedness
Dizziness may develop because tadalafil lowers blood pressure or because dapoxetine affects the nervous system.
Some people feel light-headed when standing.
This can be a warning sign of orthostatic hypotension, a drop in blood pressure after changing position.
Severe dizziness may precede fainting.
Nausea and Digestive Problems
Nausea is a recognised dapoxetine side effect.
Other possible problems include diarrhoea, vomiting, stomach discomfort, and indigestion.
Tadalafil can also contribute to indigestion.
Persistent vomiting or diarrhoea can cause dehydration, which may increase the risk of dizziness.
Headache, Flushing, and Nasal Congestion
Tadalafil widens certain blood vessels, which can cause headaches, facial warmth, or a blocked nose.
Dapoxetine can also cause headaches.
Other reported tadalafil effects include back pain and muscle aches.
Common side effects associated with Tadapox ingredients.
Side Effect | Possible Contributing Ingredient | What to Watch For |
Dizziness | Tadalafil or dapoxetine | Light-headedness when standing |
Nausea | Mainly dapoxetine | Persistent sickness or vomiting |
Headache | Both ingredients | Pain that becomes severe |
Flushing | Mainly tadalafil | Warmth or facial redness |
Indigestion | Tadalafil or dapoxetine | Stomach discomfort |
Diarrhoea | Mainly dapoxetine | Dehydration |
Back or muscle pain | Mainly tadalafil | Persistent discomfort |
Sleepiness | Dapoxetine | Reduced alertness |
These effects are based on information about the individual ingredients, not a clinical trial establishing their frequency for Tadapox specifically.
Why Can Tadapox Cause Dizziness or Fainting?
Dizziness deserves particular attention because dapoxetine has been associated with fainting.
Fainting, medically called syncope, is a temporary loss of consciousness.
The Australian Priligy prescribing information identifies dizziness, nausea, orthostatic hypotension, and syncope among important dapoxetine safety concerns.
What Warning Signs May Appear?
A person may experience:
Sudden light-headedness
Nausea
Sweating
Blurred vision
Weakness
An unusual heartbeat
These symptoms may occur before fainting, although fainting can also happen without warning.
If you feel faint, immediately sit or lie down to prevent injury.
Do not drive while dizzy or drowsy.
Is the Tadalafil–Dapoxetine Combination Safe?
The Australian prescribing information for Priligy advises against using dapoxetine with PDE5 inhibitors, including tadalafil, because of possible reduced tolerance to standing-related blood-pressure changes.
Some supervised clinical studies have investigated these medicines together, but those findings do not establish that a particular Tadapox product is safe for unsupervised use.
The combination warrants medical review before use.
Dizziness after Tadapox should not automatically be dismissed as a minor side effect. It may signal a drop in blood pressure or an approaching fainting episode, particularly when combined with alcohol or other medicines.
Can Tadapox Cause Serious Side Effects?
Yes. Rare but serious reactions associated with the ingredients include prolonged erections, sudden changes in hearing or vision, severe blood-pressure reduction, and certain neurological reactions.
Prolonged or Painful Erections
Tadalafil can rarely cause priapism, an erection lasting longer than four hours.
This requires emergency treatment because prolonged erections can permanently damage penile tissue.
Do not wait for the erection to become painful.
Sudden Vision or Hearing Changes
Sudden vision loss or reduced hearing has been reported with PDE5 inhibitors, including tadalafil.
These events are uncommon, and a direct causal relationship is not always established.
Nevertheless, they require immediate medical assessment.
The US tadalafil prescribing information explains these warnings and the risk of serious blood-pressure interactions.
Serotonin Syndrome
Dapoxetine affects serotonin, a chemical messenger in the nervous system.
Combining it with certain antidepressants, tramadol, or other medicines that increase serotonin can cause serotonin syndrome.
Warning signs may include agitation, fever, excessive sweating, tremor, muscle stiffness, diarrhoea, and confusion.
Severe symptoms require emergency care.
Tadapox-related warning symptoms and when to seek medical help.
Symptom | Possible Concern | Recommended Action |
Mild headache or flushing | Known medicine effect | Discuss if persistent |
Significant dizziness | Possible blood-pressure reduction | Sit or lie down; seek assessment |
Fainting | Possible serious reaction | Obtain urgent medical care |
Erection lasting over four hours | Priapism | Emergency treatment |
Sudden hearing or vision loss | Potential serious adverse event | Immediate medical assessment |
Fever with confusion and muscle stiffness | Possible serotonin syndrome | Emergency treatment |
Chest pain or severe breathlessness | Possible cardiovascular emergency | Call emergency services |
Which Medicines and Conditions Make Tadapox Riskier?
Medication interactions are among the most important concerns.
Nitrates and Blood Pressure Medicines
Tadalafil must not be combined with nitrate medicines used for chest pain, such as nitroglycerin or isosorbide.
The combination can cause a dangerous fall in blood pressure.
Riociguat, used for certain forms of pulmonary hypertension, is another contraindicated medicine.
Alpha-blockers and other blood-pressure treatments also require careful assessment.
Antidepressants and Other Serotonin-Related Medicines
Dapoxetine should not be combined with certain antidepressants, monoamine oxidase inhibitors, tramadol, or other serotonin-affecting medicines without following the relevant prescribing restrictions.
Some antifungal medicines and antibiotics may also increase drug exposure.
Existing Health Conditions
Extra caution is needed with significant heart disease, previous fainting, liver impairment, kidney problems, or a history of certain psychiatric conditions.
The European Association of Urology's guidance on premature ejaculation recognises dapoxetine as a treatment option in countries where it is approved, while highlighting dose-dependent adverse effects.
It does not establish that all fixed-dose tadalafil–dapoxetine products are suitable for every patient.
What Should You Do if Tadapox Causes Side Effects?
If you experience mild symptoms, avoid taking further doses until a healthcare professional has reviewed the reaction.
Do not increase the amount or combine Tadapox with another erection medicine.
Can Alcohol Make Side Effects Worse?
Yes. Alcohol may increase dizziness, drowsiness, reduced alertness, and the likelihood of fainting.
It may also worsen tadalafil-related blood-pressure effects.
Avoid alcohol when using dapoxetine-containing treatment.
Is Tadapox 20/60 mg Suitable for Beginners?
The marketed combination contains dapoxetine 60 mg.
For separately prescribed dapoxetine, European regulatory guidance advises against starting treatment at 60 mg because higher doses are associated with more adverse effects.
Therefore, Tadapox should not be treated as a routine first-choice medicine without professional assessment.
A doctor can evaluate ED and PE separately and discuss appropriately approved treatment options.
When Should You Seek Medical Attention?
Seek emergency care for fainting with ongoing symptoms, chest pain, severe breathing difficulty, or an erection lasting more than four hours.
Sudden loss of vision or hearing also requires immediate assessment.
If you develop marked dizziness, repeated vomiting, unusual mood changes, or persistent palpitations, contact a clinician promptly.
Always tell emergency healthcare professionals if you have recently taken tadalafil, particularly before receiving treatment for chest pain.
Conclusion
Tadapox side effects can include dizziness, nausea, headache, flushing, indigestion, and muscle discomfort. Its tadalafil and dapoxetine components also carry more serious risks, including fainting, dangerous blood-pressure interactions, prolonged erections, and rare neurological reactions. Importantly, the fixed combination requires caution because official dapoxetine information warns about concurrent use with PDE5 inhibitors.
Do not use Tadapox without medical assessment or assume that its marketed formulation is suitable for everyone. Discuss existing health conditions, current medicines, and safer treatment alternatives with a qualified doctor. Seek emergency care for chest pain, fainting, sudden sensory changes, or a prolonged erection.
Frequently Asked Questions
1. What are the most common Tadapox side effects?
Common effects associated with its ingredients include nausea, dizziness, headache, flushing, indigestion, and nasal congestion. Some people also experience diarrhoea, back pain, or sleepiness.
2. Why does Tadapox cause dizziness?
Tadalafil can lower blood pressure, while dapoxetine may cause dizziness or fainting. Their combination requires particular caution. Seek medical advice if dizziness occurs.
3. Can Tadapox cause nausea or vomiting?
Yes. Nausea is a recognised dapoxetine side effect, and vomiting can also occur. Persistent symptoms or dehydration require medical assessment.
4. Is Tadapox safe with alcohol?
Combining alcohol with dapoxetine may increase dizziness, drowsiness, and fainting risk. Alcohol can also enhance tadalafil-related blood-pressure effects. Avoid alcohol with this combination.
5. Can Tadapox cause a prolonged erection?
Yes. Tadalafil can rarely cause an erection lasting longer than four hours. This is a medical emergency, even when the erection is not painful.
6. Should I stop Tadapox if I experience side effects?
Do not take another dose until a healthcare professional has reviewed concerning symptoms. Seek emergency care for fainting, chest pain, severe allergic reactions, or an erection lasting over four hours.
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