How it works: Cenforce: Sildenafil relaxes blood vessels and increases penile blood flow.

Never combine tadalafil with nitrates Nitrate medicines include nitroglycerin and isosorbide products Tadalafil and nitrates both promote vasodilation. The official tadalafil nitrate warning lists concomitant organic nitrate use as a contraindication. If chest pain develops after tadalafil, do not self-treat it with a nitrate. Other PDE5 inhibitors Do not combine tadalafil with sildenafil, vardenafil, avanafil, or another PDE5

ED Medications PDE5 inhibitors (like sildenafil or tadalafil) Provide immediate improvement in erections

Sildenafil, tadalafil, and other PDE5 inhibitors improve the physical erectile response, particularly Earlier randomized trials have also evaluated combinations such as sildenafil plus cognitive-behavioral

only when they are appropriate for you Do not combine ED medicines with contraindicated drugs such as nitrates Prescription phosphodiesterase type 5 inhibitors—PDE5 inhibitors—such as sildenafil, tadalafil, vardenafil In particular, PDE5 inhibitors can cause dangerous drops in blood pressure when combined with nitrate

Tadalafil is not appropriate for everyone, and its interaction with nitrate medicines is particularly Nitrates and tadalafil can combine to produce a potentially dangerous drop in blood pressure. Nitrates include medicines such as: nitroglycerin; isosorbide mononitrate; and isosorbide dinitrate. Do not independently take nitrate medication after tadalafil. Tadalafil must not be combined with nitrate medicines because blood pressure can fall dangerously.

Erectile Dysfunction Medications Common ED medications include: Sildenafil Tadalafil Vardenafil Avanafil

PDE5 inhibitors such as sildenafil and tadalafil remain first-line medical treatments for many men with

PDE5 inhibitors such as sildenafil and tadalafil act directly on the nitric oxide–cGMP erection pathway

Do Not Mix with Certain Medications Avoid combining with: Antidepressants Nitrates Recreational drugs

This biological fact has led to strong marketing claims around foods containing nitrates or the amino Vegetables such as beetroot and leafy greens can provide dietary nitrates, while nuts, seeds, legumes

Some ED treatments can interact dangerously with other medicines, including nitrate drugs used for chest