Current U.S. labeling includes postmarketing reports of: Severe hypotension Seizures Hepatitis Elevated necrolysis Altered consciousness Confusion Disorientation Coma Rare fatal neurotoxicity Severe rash, seizures

Examples can include: Anticoagulants Some seizure medications Certain antibiotics Immunosuppressive drugs

Potential complications include: Confusion Disorientation Neurological symptoms Difficulty breathing Seizures

Neurological Symptoms Rarely, severe infections may contribute to: Confusion Altered mental status Seizures

pressure Serious toxicity has also been reported, including neurological effects such as confusion, seizures serious toxicity, including: Nausea Vomiting Diarrhea Low blood pressure Dizziness Problems with balance Seizures

Reactions Postmarketing reports have included serious adverse reactions such as: Severe hypotension Seizures Disorientation Rare severe neurotoxicity Significant neurological symptoms, severe rash, difficulty breathing, seizures

or magnesium Cholesterol-lowering medications such as cholestyramine Proton pump inhibitors Certain seizure

Current U.S. labeling includes postmarketing reports of serious reactions such as: Severe hypotension Seizures necrolysis Confusion Altered consciousness Rare serious neurotoxicity Severe rash, breathing difficulty, seizure

Emergency evaluation is particularly important with severe weakness, confusion, breathing difficulty, seizures

emergency care for blue or gray skin, significant breathing difficulty, severe dizziness, confusion, seizures

taking a stimulant or other cognitive-enhancing drug if you develop severe chest pain, fainting, a seizure

Call 911 immediately if a person collapses, has a seizure, has difficulty breathing, or cannot be awakened

Severe hypoglycaemia can lead to seizures, unconsciousness or coma and requires immediate assistance.

stimulant-related medicine with topiramate, a medicine also used for conditions such as migraine and seizures

chest pain or pressure; persistent severe dizziness or confusion; difficulty waking or staying awake; seizures

Naltrexone-bupropion is contraindicated in several circumstances, including uncontrolled high blood pressure, seizure